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Given the importance of social participation and the use of community-based approach in the development of communities, the present study seeks to identify the key factors affecting social participation in community-based organizations of addiction prevention with a scriptwriting approach. Research is in an inductive deductive approach, both quantitatively and qualitatively, which is applied in terms of exploratory nature and purpose. The statistical population of both qualitative and quantitative stages were experts active in the field of community-based prevention of addiction, which was selected through snowball sampling. To collect data in the qualitative stage, library studies, valid research on the subject and interviews with research samples were used. In the quantitative stage, data were collected using two Mick Mac questionnaires and status analysis. In this study, to measure validity, while using face validity, triple interaction was used and the data were analyzed with the help of SPSS software, Mikmak and ScenarioWizard. According to the research findings, 9 factors were identified as key factors affecting social participation, 30 possible situations for 9 factors and two categories of promotional and preventive scenarios for social participation in community-based organizations of addiction prevention.